Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 71 Reviews
8.3
Supplement Facts
Serving Size: 2 Vegetarian Capsules
Amount Per Serving
%DV
Thiamine (vitamin B1) (as thiamine HCl)
100 mg
8333%
Riboflavin (vitamin B2) (as riboflavin and riboflavin 5'-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
100 mg•
625%
Vitamin B6 (as pyridoxine HCl and pyridoxal 5' phosphate)
100 mg
5882%
Folate (as L-5-methyltetrahydrofolate calcium salt)
680 mcg○
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12500%
Biotin
1000 mcg
3333%
Pantothenic acid (as D-calcium pantothenate)
500 mg
10000%
Calcium (as D-calcium pantothenate, dicalcium phosphate)
50 mg
4%
Inositol
100 mg
**
PABA (para-aminobenzoic acid)
50 mg
**
Top Medical Research Studies
8
We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
Read More
8
Pernicious anemia misdiagnosed as fibromyalgia
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
Read More
8
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Read More
Most Useful Reviews
9
Visible improvements
290 people found this helpful
An excellent form of B vitamins. I noticed a much calmer and cheerier mood in my teenager, along with increased strength and endurance. I'm very pleased with the effects of this vitamin. We will undoubtedly order more from this company! The results are evident, as blood tests for my child with a B12 deficiency returned to normal. This form of the drug truly works and is well absorbed!
Read More
9
Better overall wellbeing
235 people found this helpful
Following my doctor's recommendation, I ordered this product containing all the B vitamins. After just a few days, I feel significantly better. Previously, I was taking vitamin D, but now my mood is better, I've gained energy, and apathy is fading. I highly recommend it to everyone! The order arrived swiftly—thank you very much!
Read More
9
Improved health outcomes
202 people found this helpful
I purchased this complex for myself and my parents on my doctor's advice due to iron deficiency anaemia and high homocysteine levels. My doctor recommended several pharmacy drugs that contained harmful substances, but this bioactive complex has everything necessary. I am extremely satisfied with its effects, and there are no observed side effects. I feel great! Its price and quality ratio are excellent.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
9
Biotin deficiency mimics neurological disorders
We explored three cases of biotinidase deficiency (BTD) that were misdiagnosed as neuromyelitis optica spectrum disorder (NMOSD) due to similar symptoms and neuroimaging results. Initially, two patients responded to immune therapy but later relapsed, while one showed no improvement. Interestingly, after timely diagnosis and biotin supplementation, two patients exhibited remarkable recoveries in both motor function and vision. This highlights the critical need for accurate diagnosis, as early treatment of BTD can lead to significant improvements.
Read More
8
Pernicious anemia misdiagnosed as fibromyalgia
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
Read More
8
We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.
Read More
8
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Read More
7
Vitamin B may indicate GBS severity
We aimed to see if vitamin B levels could signal the severity of Guillain-Barré syndrome (GBS) and its potential for complications like respiratory failure. Our study involved 50 GBS patients, where we examined their vitamin B and creatine kinase levels alongside their motor abilities.
Interestingly, we found that 44% of patients had low vitamin B levels, which linked strongly to GBS severity. However, while vitamin B showed predictive value, the creatine kinase levels did not relate to GBS severity.
Interestingly, we found that 44% of patients had low vitamin B levels, which linked strongly to GBS severity. However, while vitamin B showed predictive value, the creatine kinase levels did not relate to GBS severity.
Read More
User Reviews
USERS' SCORE
Good
Based on 71 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Visible improvements
290 people found this helpful
An excellent form of B vitamins. I noticed a much calmer and cheerier mood in my teenager, along with increased strength and endurance. I'm very pleased with the effects of this vitamin. We will undoubtedly order more from this company! The results are evident, as blood tests for my child with a B12 deficiency returned to normal. This form of the drug truly works and is well absorbed!
Read More
9
Better overall wellbeing
235 people found this helpful
Following my doctor's recommendation, I ordered this product containing all the B vitamins. After just a few days, I feel significantly better. Previously, I was taking vitamin D, but now my mood is better, I've gained energy, and apathy is fading. I highly recommend it to everyone! The order arrived swiftly—thank you very much!
Read More
9
Improved health outcomes
202 people found this helpful
I purchased this complex for myself and my parents on my doctor's advice due to iron deficiency anaemia and high homocysteine levels. My doctor recommended several pharmacy drugs that contained harmful substances, but this bioactive complex has everything necessary. I am extremely satisfied with its effects, and there are no observed side effects. I feel great! Its price and quality ratio are excellent.
Read More
9
Helpful for anxiety
8 people found this helpful
This product has drastically improved my seborrheic dermatitis, scalp itching, skin inflammation, hay fever, and allergies. I noticed significant improvement in my anxiety disorder and depression. The quality and quantity surpass supplements available in Japan. I feel so much better after the niacin flush; it's a normal reaction related to vitamin B3 niacin.
Read More
9
Relief from symptoms
8 people found this helpful
Life Extension Complete B is undoubtedly the best vitamin B complex I've found, both for quality and price. The standout feature is the Folate in its bioavailable form, L-5-methyltetrahydrofolate. Moreover, B12 is in the preferred methylcobalamin form. In the Philippines, the available B complexes are less effective and more expensive. Both my wife and I have been taking this for two months alongside Magnesium Taurate, which has alleviated our nerve-related symptoms like tingling in our fingers and toes, and it has improved our sleep. We received our order within two weeks, which was reasonable given the Covid-19 restrictions. We will continue using this as our regular supplement and highly recommend Life Extension Complete B.
Read More
Frequently Asked Questions
7.5
Energy boost
3 people found this helpful
I enjoyed taking this complex to manage my autoimmune thyroiditis. Within 5-7 days, my energy levels significantly improved, along with my overall well-being. I experienced mild niacin flush twice when taking it on an empty stomach but found no cause for concern as it subsided quickly. I recommend always taking the capsules with food. The dosage of niacin is reasonable compared to other brands, making this complex a great choice.
9
Improved mood
1 people found this helpful
Oh my goodness, I am incredibly surprised by this product's efficacy! I noticed a difference after the first dose—increased energy, clarity, stamina, and an uplifted mood. I've recommended it to several friends and will be ordering again, with no side effects aside from bright yellow urine!
9
Reduced anxiety
16 people found this helpful
I've been using this for a couple of years and decided it was time to leave a review. It's the best activated B complex I’ve tried! I’ve suffered from anxiety for as long as I remember, and within three months, I no longer felt anxious at all. The rash and heat reported by others is a harmless reaction to niacinamide. I highly recommend it!
7.5
Mood improvement
13 people found this helpful
After being on antidepressants for a year and losing interest in everything, my therapist recommended high doses of B vitamins. I initially took two different capsules daily, then switched to one of each alternating. The effect was clear; my mood improved, energy returned, and I found a desire to engage with life again. While the vitamins didn't eliminate all the issues treated by antidepressants, they certainly helped a lot. I later added SAM-e, and things improved further. Recommend!
9
Visible improvements
290 people found this helpful
An excellent form of B vitamins. I noticed a much calmer and cheerier mood in my teenager, along with increased strength and endurance. I'm very pleased with the effects of this vitamin. We will undoubtedly order more from this company! The results are evident, as blood tests for my child with a B12 deficiency returned to normal. This form of the drug truly works and is well absorbed!
9
Better overall wellbeing
235 people found this helpful
Following my doctor's recommendation, I ordered this product containing all the B vitamins. After just a few days, I feel significantly better. Previously, I was taking vitamin D, but now my mood is better, I've gained energy, and apathy is fading. I highly recommend it to everyone! The order arrived swiftly—thank you very much!
9
Stopped back pain
1 people found this helpful
The pain in my back stopped! Two years after giving birth, I experienced back pain and numbness in my scapula. Despite trying various remedies, only after taking this B Complex did I notice improvement: the numbness faded and the back pain disappeared. I’m truly delighted and have ordered it twice already.
9
Restored sensitivity
1 people found this helpful
Excellent! After a problematic wisdom tooth extraction, I experienced nerve damage, leaving half my mouth numb. They claimed this would last up to 6 months, but after a month of taking these vitamins, sensitivity has nearly fully returned. I'm reordering to continue! The ingredients are superb—an excellent combination in a single packet!
9
Balanced nervous system
9 people found this helpful
I’ve been taking this complex as part of an anti-stress regimen alongside melatonin and magnesium for two months, and I've certainly felt the positive effects! My nervous system is more balanced, I am less irritable, and my sleep has significantly improved. I recommend it for anyone feeling stressed, especially due to war-related pressures.
9
Relief from symptoms
8 people found this helpful
Life Extension Complete B is undoubtedly the best vitamin B complex I've found, both for quality and price. The standout feature is the Folate in its bioavailable form, L-5-methyltetrahydrofolate. Moreover, B12 is in the preferred methylcobalamin form. In the Philippines, the available B complexes are less effective and more expensive. Both my wife and I have been taking this for two months alongside Magnesium Taurate, which has alleviated our nerve-related symptoms like tingling in our fingers and toes, and it has improved our sleep. We received our order within two weeks, which was reasonable given the Covid-19 restrictions. We will continue using this as our regular supplement and highly recommend Life Extension Complete B.
9
Emotional relief
7 people found this helpful
This B complex was a lifesaver during a depressed phase. I had other health issues, leading me to an endocrinologist who recognised my anxiety. I was advised to take vitamin B6 in a high dosage, and this complex met that requirement. I began to feel calm after a few days and now use it for maintenance. The quality and effect are impressive.
7.5
Effective for teenagers
1 people found this helpful
Methyl form B12 in effective dosages! It's suitable for teenagers! However, please avoid self-medication. We had it prescribed after thorough testing. B vitamins improved well after 3 months. Initially, we worried about allergic reactions but were reassured by our doctor that it was normal. I recommend this supplement!
8
Pernicious anemia misdiagnosed as fibromyalgia
We explored a notable case of a woman suffering from pernicious anemia, an autoimmune condition that can be misdiagnosed due to its vague symptoms like fatigue and cognitive issues.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
After years of struggling with these nonspecific symptoms, her low vitamin B12 levels were finally identified as the underlying cause.
Upon receiving treatment with vitamin B12, she experienced neurological improvements, highlighting the importance of recognizing this deficiency, even when traditional anemia indicators are absent.
8
We explored the influence of Nicotinamide (NAM), a form of vitamin B3, on dendritic cells (DCs) in autoimmune diseases. Our research indicates that NAM can effectively reduce the overactivation of DCs, helping to ease symptoms in conditions like psoriasis.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
Through detailed analysis of available studies, we found that NAM affects DCs via a specific signaling pathway, ultimately offering a potential new direction for treatment. Importantly, these findings highlight NAM’s significant role in managing autoimmune disorders related to immune response regulation.
References
- Jatav VS, Sardana V, Bhushan B, Maheshwari D, Garg S, et al. Correlation of Serum Vitamin B and Muscle Enzyme (CK-NAC) Level with Severity of Guillain-Barre Syndrome and Its Prediction in Respiratory Failure. J Assoc Physicians India. 2025;73:48. 10.59556/japi.73.0892
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. 10.1186/s13256-025-05149-7
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. 10.1186/s13256-025-05095-4
- Cao AP, Wang YY, Shen YY, Liu YH, Liu JY, et al. Nicotinamide Suppresses Hyperactivation of Dendritic Cells to Control Autoimmune Disease through PARP Dependent Signaling. Nutrients. 2024;16. 10.3390/nu16162665
- Ali F, Mukhtiar K, Raza M, Ibrahim S. Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder. BMJ Case Rep. 2024;17. 10.1136/bcr-2023-258703
